Fig. 2
From: Pathophysiology and therapeutic potential of cardiac fibrosis
Current strategies for cardiomyocyte regeneration. a Endogenous cardiac regeneration is primarily driven by the division of pre-existing CMs; currently, paracrine factors, the microenvironment, and small molecules that regulate this process are under investigation. b The direct reprogramming of cardiac fibroblasts into CMs is induced by a combination of cardiac-specific transcription factors and compounds. Investigations to improve the efficiency and maturity of generated CMs are currently in progress