Fig. 9From: Molecular biology of autoinflammatory diseasesAutoinflammatory disease-related NF-κB activation pathway. In normal, upon recognition of DAMPs, PAMPs, or appropriate ligands, TLR, TNFR, Nod1, and Nod2 activate NF-κB. Dysregulations of the NF-κB signaling are closely linking to autoinflammatory diseases called relopathies. The NF-κB activation pathway is regulated by polyubiquitination chainsBack to article page