Fig. 5
Involvement of MMP-9 in Aβ accumulation during acute colitis. A Schematic diagram of the experimental design to induce acute DSS colitis and administration of inhibitors. AppNL-G-F mice given water or 2% DSS were injected with DNase, MMP-9 inhibitor, or NAC. B The body weight of the mice. C The colon length of the mice. D The percentage of Aβ plaque area in cortex and hippocampus by immunohistochemical staining of Aβ plaques. E Feature plot of the expression levels of Ly6g, A100a8, and Mmp9 in immune cells in the brain with acute colitis. F Violin plot of the expression of Mmp9 in the different cell clusters in the brain with acute colitis. Data points are individual mice in one experiment. P values were determined by two-tailed Mann-Whitney U test (C, D). Data are shown as the mean ± s.e.m