Fig. 5

Bone regeneration after the administration of Runx2 and/or VEGF mRNAs into mandible bone defect. A Schematic showing the schedule of mRNA administration and μCT imaging. B Representative 3D reconstruction images after the mRNA administration: Blank control, administration of only Hepes buffer, administration of Luc2 mRNA, Runx2 mRNA, VEGF mRNA, and coadministration of Runx2 and VEGF mRNAs. Each mRNA administration was done using polyplex nanomicelle