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Fig. 6 | Inflammation and Regeneration

Fig. 6

From: A Sox17 downstream gene Rasip1 is involved in the hematopoietic activity of intra-aortic hematopoietic clusters in the midgestation mouse embryo

Fig. 6

Formation of IAHCs involving Rasip1. A model of Rasip1 function in IAHCs. Sox17 induces the expression of Rasip1 which eventually leads to the hematopoietic activity of HSCs in IAHCs. Upper panel: Function of Rasip1 revealed by knockdown experiments. Forced expression of Sox17 (Sox17 OE) in CD45lowc-Kithigh cells was known to maintain the formation of hematopoietic cell clusters. However, the downstream signaling involved remained poorly understood. A current study has revealed that Rasip1 knockdown (Rasip1 KD) decreases hematopoietic activity and cluster formation. Lower panel: Effect of Rasip1 overexpression (Rasip1 OE) in CD45lowc-Kithigh cells. Rasip1 OE leads to a significant but transient increase in the hematopoietic activity, suggesting the presence of a cooperating factor for sustained hematopoietic activity

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Inflammation and Regeneration

ISSN: 1880-8190

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