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Fig. 6 | Inflammation and Regeneration

Fig. 6

From: Placenta mesenchymal stem cell-derived extracellular vesicles alleviate liver fibrosis by inactivating hepatic stellate cells through a miR-378c/SKP2 axis

Fig. 6

Identifying miR-378c as effective anti-fibrosis content in Pd-MSCs-EVs. A miR-seq was performed to identify differential miRNAs between fibrosis organoid model with or without Pd-MSCs-EVs administration. B The differential miRNAs were validated by RT-qPCR. C miR-378c expression in two GEO datasets regarding liver fibrosis. D miR-378c expression in extracellular vesicles derived from MSCs with or without miR-378c inhibitors. E, F The expression of fibrotic markers in different groups was detected by RT-qPCR and immunofluorescence. G The expression of EMT markers in different groups was detected by immunofluorescence. TGF-β1, transformation growth factor- beta; α-SMA, α-smooth muscle actin. **P < 0.01

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Inflammation and Regeneration

ISSN: 1880-8190

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