Fig. 7

Pd-MSCs derived miR-378c inactivated HSCs. A–C CCK8, transwell, and flowcytometry assays were performed to detect the proliferation, migration, and cell cycle distribution of HSCs in each group. D Western blotting was used to detect the expression of fibrotic and EMT markers of HSCs at each group. E Uptake of extracellular vesicles by HSCs through PKH67 and PKH26 staining. F–H After different treatments, the secretion, proliferation, and migration activities of HSCs were detected by ELISA, EdU, and transwell assays, respectively. I The expression of fibrotic markers in HSCs at different groups was detected by immunofluorescence. TGF-β1, transformation growth factor- beta; α-SMA, α-smooth muscle actin. *P < 0.05; **P < 0.01