Skip to main content
Fig. 3 | Inflammation and Regeneration

Fig. 3

From: Analysis of distribution, collection, and confirmation of capacity dependency of small extracellular vesicles toward a therapy for liver cirrhosis

Fig. 3

Uptake of tdTomato expressing small extracellular vesicles (sEVs) into cirrhotic livers. A Schematic of injection of tdTomato expressing sEVs in the part of the right lobe of murine cirrhotic livers. Red arrows show the flow of injected sEVs. Green X and arrows show ligatures. Red dots shows the area of sEVs injection. B, C Observations after administration of control sEVs (B) and tdTomato expressing sEVs (C) in the 8 weeks CCl4 damaged livers. D, E Observations after administration of control sEVs (D) and tdTomato-expressing sEVs (E) when macrophages were made recognizable by AlexaFluor 488 (green) in the 8 weeks CCl4 damaged livers. 400 μl of control sEVs or tdTomato-expressing sEVs (concentration; 20 μg/mL) were injected from inferior vena cava 4 h before observation. Yellow arrows show the hepatocyte debris, which is detected in the damaged area of the liver. Scale bar, 100 μm. n = 3 per experiment

Back to article page

Inflammation and Regeneration

ISSN: 1880-8190

Contact us