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Fig. 7 | Inflammation and Regeneration

Fig. 7

From: Testosterone upregulates glial cell line-derived neurotrophic factor (GDNF) and promotes neuroinflammation to enhance glioma cell survival and proliferation

Fig. 7

The effect of GDNF knockout on inflammatory protein level, pro-inflammatory macrophage recruitment, and microglial survival. A Western blot detection of NRF2, iNOS, ERK1/2, pERK1/2, CD40L, GDNF, and Survivin in castrated, testosterone, female, and GDNF knockout (n = 3). B Immunofluorescence detection of pro-inflammatory macrophages (CD86) and microglia (Iba1) between the untreated and GDNF knockout + testosterone-treated brain tissue, Dapi was used to stain U251 nuclei (n = 3). C Edu staining comparing the untreated and GDNF knockout + testosterone treated U251 survival (n = 3). Dapi was used to stain U251 nuclei. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001

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Inflammation and Regeneration

ISSN: 1880-8190

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