Table 2 List of the studies of autoimmune disease patient-derived iPS cells
From: Investigation of immune-related diseases using patient-derived induced pluripotent stem cells
Author (Ref) | Disease | iPS cell-derived cell types | Key findings |
|---|---|---|---|
Lee et al. [48] | RA | Teratoma, osteoblast | iPS cell establishment from FLS, Osteoblast differentiation |
Rim et al. [49] | RA | iPS cells | iPS cell establishment from FLS |
Wolnik et al. [50] | RA | iPS cells | iPS cell establishment from FLS |
Lee et al. [51] | RA | Cardiomyocytes | Disfunction of RA-iPS cell derived cardiomyocyte |
Kim et al. [52] | RA | iPS cells | Different metabolic profiles between RA and OA-iPS cells. Proliferation of RA-iPS cells by NAM |
Kim et al. [53] | RA | Hepatocytes | Recapitulation of methotrexate hepatotoxicity |
Layh-Schmitt et al. [54] | AS | Mesenchymal stem cells, osteoblasts, chondrocytes, adipocytes | Elevated expression of AS susceptibility genes associated with bone formation in AS-iPS cell-derived MSCs |
Hu et al. [55] | AS | iPS cells | iPS cell establishment from a JAK2 mutated AS patient |
Hu et al. [56] | AS | iPS cells | iPS cell establishment |
Son et al. [57] | AS, SS, SLE | Hematopoietic cells, mesenchymal cells | Integrin-free iPS cell establishment |
Son et al. [58] | BD | Hematopoietic precursor cells | Elevated expression of 8 genes, including CXCL1, in BD-iPS cell-derived hematopoietic precursor cells |
Iizuka-Koga et al. [59] | SS | Dendritic cells | Functional DC differentiation from SS T cell clone-derived iPS cells |
Wang et al. [60] | SSc | Fibroblasts | Normal collagen and intergrin expression in SSc iPS cell-derived fibroblasts |
Gholami et al. [61] | SSc | Endothelial cells | Lower cadherin expression and defective tube formation in SSc iPS cell-derived ECs |
Chen et al. [62] | SLE | iPS cells | iPS cell establishment from urinal tubular cells of SLE |
Tang et al. [63] | SLE | iPS cells | Differentially expression between SLE and healthy donor iPS cells, including AK4 upregulation |
De Angelis et al. [64] | SLE | iPS cells | iPS cell establishment from a patient with CNS lupus. Increased Erk, Akt, and oxidative stress -associated pathway in SLE iPS cells |
Park et al. [65] | SLE | Cardiomyocytes | Decreased proliferation and increased levels of fibrosis and hypertrophy marker expression in SLE iPS cell-derived cardiomyocytes. Pathogenic effects of anti-Ro antibody on iPS cell-derived cardiomyocytes |
Li et al. [66] | SLE | iPS cells | iPS cell establishment |
Li et al. [67] | SLE | iPS cells | iPS cell establishment |
Natsumoto et al. [20] | SLE | CD123+ dendritic cells | iPS cell establishment from SLE sisters. Enhanced IFN-alpha secretion in DCs due to OASL variant |