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Fig. 3 | Inflammation and Regeneration

Fig. 3

From: Prime-boost-type PspA3 + 2 mucosal vaccine protects cynomolgus macaques from intratracheal challenge with pneumococci

Fig. 3

Prime-boost-type vaccination with curdlan and/or CpG-ODN can induce antigen-specific serum IgG and antigen-specific BALF IgA in macaques. A, B Body weight changes (A) and percentage body weight changes (B) after primary immunization. C, D Time course of PspA-specific IgG titers in the serum (C) and PspA-specific IgA titers in BALF (D) of macaques immunized with PspA/WOW emulsion containing curdlan and/or CpG-ODN. Results represent mean ± SEM. *P < .05 (naive vs. curdlan), ***P < .001 (naive vs. curdlan), #P < .05 (naive vs. curdlan + CpG), ###P < .001 (naive vs. curdlan + CpG) (Tukey’s post hoc test). Naive and WOW + PspA + curdlan: n = 3 macaques/group, WOW + PspA + CpG + curdlan: n = 4 macaques/group

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Inflammation and Regeneration

ISSN: 1880-8190

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