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Fig. 1 | Inflammation and Regeneration

Fig. 1

From: Regeneration of joint surface defects by transplantation of allogeneic cartilage: application of iPS cell-derived cartilage and immunogenicity

Fig. 1

Limited immunogenicity of articular cartilage. a Histological image of articular cartilage. ECM inhibits contact of immune cells with chondrocytes. b Expression of MHC-I molecules on chondrocytes. Chondrocytes stimulated with IFN-γ show increased expression of MHC-I, suggesting that in the absence of ECM, they can become immunogenic under inflammatory conditions. c Immune response in allogeneic iPSC-derived cartilage transplantation. In osteochondral defects, T cells are observed around the graft. On the other hand, the graft is engrafted without immune response in chondral defects

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Inflammation and Regeneration

ISSN: 1880-8190

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