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Fig. 1 | Inflammation and Regeneration

Fig. 1

From: TNF-α and IFN-γ prestimulation enhances the therapeutic efficacy of human amniotic epithelial stem cells in chemotherapy-induced ovarian dysfunction

Fig. 1

Effect of chemotherapy drugs on ovaries at different time points. A Images showing the ovaries in the sham and chemotherapy (Cy)-treated groups on days 1, 3, 7, and 14. B The columns showed the body weight and ovarian weight of mice in the sham and Cy-treated groups. C Images showing HE staining of ovarian sections from the sham and Cy-treated groups. The asterisk represented a naked oocyte. Scale bars, 500 μm and 100 μm. D The columns showed the number of follicles at different stages, including primordial follicles, primary follicles, secondary follicles, and antral follicles, as well as the number of abnormal follicles and atretic follicles. E Representative images showing Ki-67 expression in ovarian sections from the sham and Cy-treated groups. Scale bars, 50 μm and 25 μm. F, G The protein expression of PCNA in ovaries was examined and analyzed at different time points after chemotherapy. H, I The expression of follicular activation-related proteins was examined and analyzed at different time points after chemotherapy. N=4 per group. The data were presented as the mean±SEM. *P<0.05, **P<0.01, ***P<0.005, and ****P<0.001. Cy, chemotherapy; PCNA, proliferating cell nuclear antigen

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Inflammation and Regeneration

ISSN: 1880-8190

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