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Fig. 5 | Inflammation and Regeneration

Fig. 5

From: Novel artificial nerve transplantation of human iPSC-derived neurite bundles enhanced nerve regeneration after peripheral nerve injury

Fig. 5

Transcriptome analysis 1 week after neurite bundle-derived artificial nerve transplantation. a Principal component analysis of the gene expression data in peripheral nerves at 1 week after transplantation. The spatial arrangement of the points reflects the overall data similarity between the samples. b Gene expression MA plots between the following paired group comparison. Red and blue plots indicate differentially expressed genes (p < 0.05, fold change > 1.5). Top left: Motor TP vs. NC. Bottom left: Sensory TP vs. NC. Right: Motor TP vs. Sensory TP. c, d  Dot plot of the top 15 GO biological process terms associated with genes with upregulated expression in the motor TP (c) and sensory TP groups (d) compared with the NC group. e, f  Heatmap of the expression values (normalized as TPM) of various genes associated with macrophages and regeneration in the motor TP, sensory TP and NC groups

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Inflammation and Regeneration

ISSN: 1880-8190

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