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Fig. 4 | Inflammation and Regeneration

Fig. 4

From: Rapid and high-purity differentiation of human medium spiny neurons reveals LMNB1 hypofunction and subtype necessity in modeling Huntington’s disease

Fig. 4

MSNs recapitulated the HD pathology. A–E Neural development in both WT and HD neurons. The neurite lengths (6 dpi), soma sizes (21 dpi), and primary branch numbers (21 dpi) were assessed, respectively. The maturation of neurons was assessed by Sholl analysis. Scale bars, 50 μm. F–L Expression of typical genes affected by HD in differentiated neurons was detected by quantitative PCR. M–N Neuronal death upon BDNF withdrawal was assessed by Annexin V staining. Scale bars, 50 μm. *p < 0.05; **p < 0.01; ***p < 0.001

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Inflammation and Regeneration

ISSN: 1880-8190

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