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Fig. 6 | Inflammation and Regeneration

Fig. 6

From: Rapid and high-purity differentiation of human medium spiny neurons reveals LMNB1 hypofunction and subtype necessity in modeling Huntington’s disease

Fig. 6

LMNB1 mislocalization and hypofunction in HD-MSNs. A–C Both WT and HD neurons on the glia layer were immunostained by LMNB1. Prominent LMNB1 mislocalizations into the cytoplasm were observed in HD neurons. Dashed circles denote nucleus. Scale bars, 20 μm. D, E LMNB1 levels were detected by immunoblot in differentiated neurons. F, G HTT knockdown or KPT335 treatment effectively ameliorated the LMNB1 mislocalization. H HTT knockdown or KPT335 treatment attenuated neuronal death upon BDNF withdrawal. However, the therapeutic effects of HTT knockdown were partially diminished by LMNB1 knockdown. *p < 0.05; **p < 0.01; ***p < 0.001

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Inflammation and Regeneration

ISSN: 1880-8190

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