Fig. 3
From: The gateway reflex regulates tissue-specific autoimmune diseases
Stress-mediated neuropsychiatric systemic lupus erythematosus (NPSLE) mouse model. A cartoon of the mouse model. (1) Stress is induced by sleep deprivation (SD). (2) Neurons in the mPFC are activated, leading to the activation of microglia. (3) IL-12/23p40 is produced from the microglia. (4) IL-12/23p40 induces the activation of neurons in the mPFC to abnormally activate neural circuits, leading to (5) neuropsychiatric phenotypes. mPFC, medial prefrontal cortex