Fig. 1
From: Regulation of inflammatory diseases via the control of mRNA decay
Domain structures of ZFP36, Regnase, and Roquin family proteins. Immune-related RNA-binding proteins (RBPs) such as ZFP36, Regnase, and Roquin family proteins share the common CCCH-type zinc finger (ZF) domain. The TTP family contains tandem ZF domains. The Regnase family features a PIN-like RNase domain, alongside ZF domains, as well as N-terminal (NTD) and C-terminal (CTD) domains. Roquin family proteins possess the ROQ domain, a RING finger domain, and ZF domains. The multiple RNA-binding domains of these proteins facilitate complex RNA recognition