Fig. 3
From: Regulation of inflammatory diseases via the control of mRNA decay
Post-transcriptional mRNA mark recognition by RNA-binding proteins. mRNAs encoding inflammation-related genes contain cis-elements and RNA modifications crucial for post-transcriptional regulation. AU-rich elements (AREs) and stem-loops (A, B) are cis-elements recognized by multiple RBPs, either destabilizing or stabilizing target mRNAs. Additionally, RNA m6A modifications (m6A) deposited by m6A writer proteins are recognized by direct and/or indirect m6A reader proteins (C), influencing post-transcriptional regulations. The m6A modification can also be removed by m6A erasers