Fig. 4

Designer therapeutic cells for tissue regeneration. Designer therapeutic cells are engineered using synNotch to recognize abnormal cells or damage markers specific to damaged tissues. Designer cells then produce a combination of therapeutic factors, including growth factors, cytokines, and biologics, which have different functions to support tissue regeneration by removing damage-related abnormal factors and inducing the proliferation and differentiation of stem cells. Using designer therapeutic cells, potent therapeutic factors can be delivered specifically to damaged tissues with less toxicity to healthy tissues