Fig. 6

TN-C deficiency aggravates the disease severity of BPD. To establish the BPD model, newborn mice were exposed to 85% oxygen from postnatal day (P) 1 to P7, after which the mice were placed under normoxic conditions until P14. A Lung TN-C expression was abolished in knockout mice via Western blotting analysis. B Representative H&E-stained lung sections at P14. Scale bar = 100 μm. C-D The TN-C KO mice exhibited a lower RAC and a greater MLI than did the wild-type mice reared under hyperoxia from birth to P7