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  1. Review

    Roles of renin-angiotensin system and Wnt pathway in aging-related phenotypes

    The renin-angiotensin system (RAS) regulates diverse cellular responses and is crucial for normal organ development and function. On the other hand, RAS exerts deleterious effects promoting cardiovascular and ...

    Takehiro Kamo, Hiroshi Akazawa, Jun-ichi Suzuki and Issei Komuro

    Inflammation and Regeneration 2016 36:12

    Published on: 9 August 2016

  2. Review

    RANKL system in vascular and valve calcification with aging

    Vascular and cardiac valve calcification is associated with cardiovascular mortality in the general population. Increasing clinical and experimental evidence suggests that inflammation accelerates the progress...

    Ryo Kawakami, Hironori Nakagami, Takahisa Noma, Koji Ohmori, Masakazu Kohno and Ryuichi Morishita

    Inflammation and Regeneration 2016 36:10

    Published on: 1 August 2016

  3. Review

    BAFF- and APRIL-targeted therapy in systemic autoimmune diseases

    B cells play a pivotal role in autoimmunity not only by producing pathogenic autoantibodies but also by modulating immune responses via the production of cytokines and chemokines. The B cell-activating factor/...

    Shingo Nakayamada and Yoshiya Tanaka

    Inflammation and Regeneration 2016 36:6

    Published on: 21 July 2016

  4. Review

    GM-CSF as a therapeutic target in autoimmune diseases

    Granulocyte-macrophage colony-stimulating factor (GM-CSF) has been known as a hematopoietic growth factor and immune modulator. Recent studies revealed that GM-CSF also had pro-inflammatory functions and contr...

    Aoi Shiomi, Takashi Usui and Tsuneyo Mimori

    Inflammation and Regeneration 2016 36:8

    Published on: 5 July 2016

  5. Review

    Dysfunctional immunoproteasomes in autoinflammatory diseases

    Recent progress in DNA sequencing technology has made it possible to identify specific genetic mutations in familial disorders. For example, autoinflammatory syndromes are caused by mutations in gene coding fo...

    Hideki Arimochi, Yuki Sasaki, Akiko Kitamura and Koji Yasutomo

    Inflammation and Regeneration 2016 36:13

    Published on: 28 May 2016

  6. Review

    Metabolic regulation by secreted phospholipase A2

    Within the phospholipase A2 (PLA2) superfamily that hydrolyzes phospholipids to yield fatty acids and lysophospholipids, the secreted PLA2 (sPLA2) enzymes comprise the largest family that contains 11 isoforms in ...

    Hiroyasu Sato, Yoshitaka Taketomi and Makoto Murakami

    Inflammation and Regeneration 2016 36:7

    Published on: 21 May 2016

  7. Review

    Usefulness of nailfold videocapillaroscopy for systemic sclerosis

    Systemic sclerosis is a complex disease that involves “autoimmunity,” “inflammation,” “fibrosis,” and “vasculopathy.” Microvascular damage and dysfunction particularly represent the earliest morphological and ...

    Satoshi Kubo and Yoshiya Tanaka

    Inflammation and Regeneration 2016 36:5

    Published on: 25 April 2016

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