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  1. Review

    Cancer cell reprogramming to identify the genes competent for generating liver cancer stem cells

    The cancer stem cell (CSC) hypothesis postulates that cancer originates from the malignant transformation of stem/progenitor cells and is considered to apply to many cancers, including liver cancer. Identifica...

    Kenly Wuputra, Chang-Shen Lin, Ming-Ho Tsai, Chia-Chen Ku, Wen-Hsin Lin, Ya-Han Yang, Kung-Kai Kuo and Kazunari K. Yokoyama

    Inflammation and Regeneration 2017 37:15

    Published on: 18 May 2017

  2. Review

    Applications of reconstituted inflammasomes in a cell-free system to drug discovery and elucidation of the pathogenesis of autoinflammatory diseases

    The inflammasome, typically consisting of a Nod-like receptor, apoptosis-associated speck-like protein, and pro-caspase-1, has recently been identified as a huge intracellular complex, which plays a crucial ro...

    Naoe Kaneko, Tomoyuki Iwasaki, Yuki Ito, Hiroyuki Takeda, Tatsuya Sawasaki, Shinnosuke Morikawa, Naoko Nakano, Mie Kurata and Junya Masumoto

    Inflammation and Regeneration 2017 37:9

    Published on: 3 May 2017

  3. Review

    Isolation of dental pulp stem cells with high osteogenic potential

    Dental pulp stem cells/progenitor cells (DPSCs) can be easily obtained and can have excellent proliferative and mineralization potentials. Therefore, many studies have investigated the isolation and bone forma...

    Takazumi Yasui, Yo Mabuchi, Satoru Morikawa, Katsuhiro Onizawa, Chihiro Akazawa, Taneaki Nakagawa, Hideyuki Okano and Yumi Matsuzaki

    Inflammation and Regeneration 2017 37:8

    Published on: 10 April 2017

  4. Review

    Pharmacological targeting of bone marrow mesenchymal stromal/stem cells for the treatment of hematological disorders

    The therapeutic effects of mesenchymal stromal/stem cells (MSCs) are mainly based on three characteristics: immunomodulation, tissue regeneration, and hematopoietic support. Cell therapy using culture-expanded...

    Noriko Sugino, Tatsuo Ichinohe, Akifumi Takaori-Kondo, Taira Maekawa and Yasuo Miura

    Inflammation and Regeneration 2017 37:7

    Published on: 3 April 2017

  5. Review

    The roles of RGMa-neogenin signaling in inflammation and angiogenesis

    Repulsive guidance molecule (RGM) is a glycosylphosphatidylinositol (GPI)-anchored glycoprotein that has diverse functions in the developing and pathological central nervous system (CNS). The binding of RGM to...

    Yuki Fujita and Toshihide Yamashita

    Inflammation and Regeneration 2017 37:6

    Published on: 8 March 2017

  6. Research article

    Effect of human umbilical cord blood stem cell transplantation on oval cell response in 2-AAF/CCL4 liver injury model: experimental immunohistochemical study

    Oval cells, specific liver progenitors, are activated in response to injury. The human umbilical cord blood (hUCB) is a possible source of transplantable hepatic progenitors and can be used in cases of severe ...

    Hussein Abdellatif, Gamal Shiha, Dalia M. Saleh, Huda Eltahry and Kamal G. Botros

    Inflammation and Regeneration 2017 37:5

    Published on: 6 February 2017

  7. Research article

    Neuroprotective effects of human umbilical cord-derived mesenchymal stem cells on periventricular leukomalacia-like brain injury in neonatal rats

    Periventricular leukomalacia (PVL) is a type of multifactorial brain injury that causes cerebral palsy in premature infants. To date, effective therapies for PVL have not been available. In this study, we exam...

    Chikako Morioka, Motohiro Komaki, Atsuko Taki, Izumi Honda, Naoki Yokoyama, Kengo Iwasaki, Sachiko Iseki, Tomohiro Morio and Ikuo Morita

    Inflammation and Regeneration 2017 37:1

    Published on: 16 January 2017

  8. Review

    Dissecting cellular senescence and SASP in Drosophila

    Cellular senescence can act as both tumor suppressor and tumor promoter depending on the cellular contexts. On one hand, premature senescence has been considered as an innate host defense mechanism against car...

    Takao Ito and Tatsushi Igaki

    Inflammation and Regeneration 2016 36:25

    Published on: 5 December 2016

  9. Review

    Organ dysfunction as a new standard for defining sepsis

    Despite advances in intensive care and the widespread use of standardized care included in the Surviving Sepsis Campaign Guidelines, sepsis remains a leading cause of death, and the prevalence of sepsis increa...

    Seitaro Fujishima

    Inflammation and Regeneration 2016 36:24

    Published on: 15 November 2016

  10. Review

    Liver regeneration and fibrosis after inflammation

    The liver is a unique organ with an extraordinary capacity to regenerate upon various injuries. In acute and transient liver injury by insults such as chemical hepatotoxins, the liver in rodents returns to the...

    Minoru Tanaka and Atsushi Miyajima

    Inflammation and Regeneration 2016 36:19

    Published on: 18 October 2016

  11. Review

    Age-related sarcopenia and its pathophysiological bases

    Age-related loss of the skeletal muscle and its function is known as sarcopenia. Definition and diagnostic criteria for sarcopenia have been outlined as consensus statements from several study groups, includin...

    Sumito Ogawa, Mitsutaka Yakabe and Masahiro Akishita

    Inflammation and Regeneration 2016 36:17

    Published on: 7 September 2016

  12. Review

    Inflammatory predisposition predicts disease phenotypes in muscular dystrophy

    Duchenne muscular dystrophy is an incurable genetic disease that presents with skeletal muscle weakness and chronic inflammation and is associated with early mortality. Indeed, immune cell infiltration into th...

    Yuko Nitahara-Kasahara, Shin’ichi Takeda and Takashi Okada

    Inflammation and Regeneration 2016 36:14

    Published on: 5 September 2016

  13. Research article

    Mycobacterium avium infection induces the resistance of the interferon-γ response in mouse spleen cells at late stages of infection

    Bacterial infections cause an increase in the population of hematopoietic stem cells (HSCs). To investigate the downstream factors associated with hematopoietic stem cells, mice are infected with Mycobacterium av...

    Atsuko Masumi, Keiko Mochida, Kazuya Takizawa, Takuo Mizukami, Madoka Kuramitsu, Momoka Tsuruhara, Shigetarou Mori, Keigo Shibayama, Kazunari Yamaguchi and Isao Hamaguchi

    Inflammation and Regeneration 2016 36:21

    Published on: 26 August 2016

  14. Review

    The pathological role of vascular aging in cardio-metabolic disorder

    Chronological aging is linked to cellular senescence, and there is accumulating evidence for a pathological role of cellular senescence in age-related disorders such as obesity, diabetes, and heart failure. Th...

    Goro Katsuumi, Ippei Shimizu, Yohko Yoshida and Tohru Minamino

    Inflammation and Regeneration 2016 36:16

    Published on: 16 August 2016

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