Fig. 2

Regenerative therapy using controlled release of recombinant human fibroblast growth factor. Schematic views and photographs of the surgical procedure using recombinant human fibroblast growth factor (rhFGF)-2-impregnated gelatin hydrogel for patients with precollapse stage of osteonecrosis of the femoral head (ONFH) are shown. a A schema of the surgical procedure administering the rhFGF-2 gelatin hydrogel. The rhFGF-2-impregnated gelatin hydrogel is embedded percutaneously over the lateral aspect of the femur near the level of the lesser trochanter. A small photograph on the left side shows the actual gelatin hydrogel, which is a superior slow-release carrier for growth factors. b A representative intraoperative fluoroscopic image at drilling. c A screenshot of the preoperative planning using navigation software is shown. The yellow area shows the area of ONFH. The surgeon planned the suitable route of drilling (blue screw)