Fig. 1From: Metabolic regulation by secreted phospholipase A2 PLA2 reaction. PLA2 hydrolyzes the sn-2 position of glycerophospholipids to yield fatty acids (typically unsaturated) and lysophospholipids. Phospholipases A1, C, and D (PLA1, PLC, and PLD, respectively) cleave other ester bonds in the glycerophospholipid molecule. Unsaturated fatty acids and lysophospholipids are further metabolized to a variety of lipid mediatorsBack to article page