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Fig. 2 | Inflammation and Regeneration

Fig. 2

From: Metabolic regulation by secreted phospholipase A2

Fig. 2

Metabolic regulation by “metabolic sPLA2s.” During obesity, two sPLA2s (IIE and V) are induced in hypertrophic adipocytes. sPLA2-IIE hydrolyzes PE and PS in lipoproteins (VLDL, LDL, and HDL) and facilitates fat accumulation into the peripheral tissues. sPLA2-V hydrolyzes PC in LDL to release oleate and linoleate, which counteracts the palmitate-induced M1 polarization of macrophages and thereby sequesters adipose tissue inflammation [18]

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