Fig. 3From: Metabolic regulation by secreted phospholipase A2 Immune balance regulation by sPLA2-V. sPLA2-V is induced in the M2 macrophages and Th2 cells by IL-4 or IL-13 and promotes Th2/M2-dominant immunity such as asthma [31, 32]. Conversely, sPLA2-V plays protective roles in Th1- or Th17-type immune responses including obesity, infection, and arthritis [10, 18, 34]Back to article page