Fig. 1
From: Roles of renin-angiotensin system and Wnt pathway in aging-related phenotypes
RAS signaling and Wnt signaling in aging process. AT1 receptor is activated upon stimulation by binding of Ang II or mechanical stress, and Wnt/β-catenin signaling cascade is initiated by binding of Wnt proteins or C1q-r-s complex to Frizzled receptor. Both AT1 receptor signaling and Wnt/β-catenin signaling are essential for normal organ development and crucial for regulation of physiological homeostasis. On the other hand, AT1 receptor signaling and Wnt/β-catenin signaling are involved in the aging process, and they are hierarchically related in promoting aging-related phenotypes. AT1 receptor blockade protects against aging-related deleterious effects through down-regulation of aging-promoting C1q-Wnt/β-catenin signaling pathway