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Fig. 1 | Inflammation and Regeneration

Fig. 1

From: Inflammatory predisposition predicts disease phenotypes in muscular dystrophy

Fig. 1

Function of interleukin (IL)-10 as an important immunomodulator that could regulate Duchenne muscular dystrophy (DMD) pathogenesis. In a dystrophic muscle, the inflammatory macrophage producing IL-1α, IL-1β, IL-1ra, IL-16, RANTES, M-CSF, MIG, JE/MCP-1, and TIMP-1 is regulated by IL-10. IL-10 might be an important immune-modulator in dystrophic muscles, because IL-10 ablation in mdx mice causes an increase in inflammation, muscle necrosis, and fibrosis

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