Fig. 2From: The pathological role of vascular aging in cardio-metabolic disorderThe role of vascular aging and hypoxia-induced BAT dysfunction in obesity. Metabolic stress up-regulates p53 in endothelial cells and reduces the activation of eNOS and GLUT1 level. This leads to reduced PGC1-α expression in skeletal muscle leading to the development of systemic metabolic dysfunction. In brown adipose tissue (BAT), metabolic stress promotes capillary rarefaction by the suppression of VEGF-A, and this leads to the whitening of BATBack to article page