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Fig. 1 | Inflammation and Regeneration

Fig. 1

From: Receptor-associated prorenin system contributes to development of inflammation and angiogenesis in proliferative diabetic retinopathy

Fig. 1

A schema showing the significant involvement of retinal RAPS (a) and vitreous RAS (b) with the VEGF-driven pathogenesis of diabetic retinopathy. Vitreous RAS is caused by s(P)RR, whereas retinal RAPS depends on membrane-type (P)RR (modified from Kanda et al. [27]). ACE angiotensin-converting enzyme, AGT angiotensinogen, Ang I angiotensin I, Ang II angiotensin II, AT1R angiotensin II type 1 receptor, ERK extracellular signal-regulated kinase, NF-kB nuclear factor-kB, (P)RR (pro)renin receptor

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