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Fig. 2 | Inflammation and Regeneration

Fig. 2

From: Neuroprotective effects of human umbilical cord-derived mesenchymal stem cells on periventricular leukomalacia-like brain injury in neonatal rats

Fig. 2

The effect of UCMSCs on LPS-induced brain injury. a Graphs showed the relative intensity ratios of growth factors found in the conditioned media to that of the provided positive control. b The area of white matter was evaluated by MBP staining after MSC treatment on postnatal day 12. Representative images from each group. From the left, the saline group, LPS-control group and LPS + MSC group are shown. Scale bar: 100 μ. c Quantitative analysis of the MBP-positive areas in each group. Four sections were evaluated per pup. N = 8 in each group, values indicate means ± S.E. *, p < 0.05; assessed by t test. d The mRNA levels of pro-inflammatory cytokines and chemokines in brain tissues at 48 h after MSC treatment were determined by qRT-PCR. Relative mRNA expression levels of IL-6, TNF-α, IL-1β, and MCP-1 compared with levels in the saline group. N = 5, values indicate means ± S.E. *, p < 0.05; assessed by t test

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