Fig. 4

The effect of preconditioning of UCMSCs on the LPS-induced white matter brain injury. a The areas of white matter was evaluated by MBP staining on postnatal day 12. Representative images of each group. From the left, the saline group, LPS+ control group, LPS + MSC-CM group, and LPS + IFN-γ-MSC-CM group are shown. Scale bar: 100 μm. b Quantitative analysis of the MBP-positive area in each group. Four sections were evaluated per pup. N = 7 or 8 per group, values indicate means ± S.E. *; p < 0.05; assessed by Dunnett’s test. c Expression levels of TSG-6 and IDO in MSC stimulated with IFN-γ using quantitative RT-PCR. *, p < 0.05; assessed by t test