Fig. 2From: Pharmacological targeting of bone marrow mesenchymal stromal/stem cells for the treatment of hematological disordersMSC-based therapy with pharmacological modification of endogenous MSCs. In a conventional approach, MSCs are isolated from donors, culture-expanded ex vivo, and then infused into recipients, mainly intravenously. This intervention is a “quantity”-based strategy to achieve the therapeutic effects of MSCs (left panel). We have proposed a strategy in which pharmacological treatment activates or modifies the functions of endogenous MSCs. This intervention is a “quality”-based strategy to achieve the therapeutic effects of MSCs (right panel)Back to article page