|
Drug
|
Target cells
|
Clinical effect
|
MSC-mediated hematopoiesis
|
MSC-mediated bone regeneration
|
Mechanism(s) in MSCs
|
References
|
|---|
|
ASA
|
Broad cells
|
Anti-inflammation
|
N/T
|
↑
|
Telomerase activity↑
|
[33]
|
|
EPO
|
Erythroid progenitors
|
Erythropoiesis
|
↑
|
↑
|
EPOR/Stat5 pathway↑
|
[34]
|
|
PTH
|
Osteoblasts/Osteoclasts
|
Osteoporosis
|
↑
|
→
|
CDH11 expression↑
|
[35]
|
|
VK2
|
Osteoblasts
|
Osteoporosis
|
↑
|
↑
|
CXCL12 expression↓
|
[37]
|
|
OICS
|
N/A
|
Osteoporosis
|
↑
|
→
|
CXCL12 and VCAM1 expression↓
|
[36]
|
- Up arrows indicate up-regulation or activation. Down arrows indicate down-regulation or inactivation
-
ASA acetylsalicylic acid (aspirin), EPO erythropoietin, EPOR erythropoietin receptor, MSC mesenchymal stromal/stem cell, N/T not tested, OICS osteo-inductive cocktail (dexamethasone, phosphate, and vitamin C ), PTH parathyroid hormone, VCAM1 vascular cell adhesion protein 1, VK2 vitamin K2
