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Table 2 Studies of bone regeneration by stem cells from dental pulp in the cranio-maxillofacial region in vivo

From: Isolation of dental pulp stem cells with high osteogenic potential

Authors and year

 

Targeted site

Cell source

Selection

Host

Scaffolds

Results

de Mendonca et al. [78]

2008

Cranial bone defect

Human DPSCs

–

Rat

Collagen membrane

Induction of mature bone formation

Seo et al. [8]

2008

Critical-size calvarial bone defect

Human SHEDs

–

Mouse

HA/TCP

Repair of defects and substantial bone formation

Zheng et al. [82]

2009

Orofacial bone defects

Stem cells from porcine (miniature pig) deciduous teeth

–

Miniature pig

β-TCP

More efficient regeneration of critical-size mandibular bone defects

d’Aquino et al. [83]

2009

Alveolar bone defect after extraction of impacted third molars

Human DPSCs

–

Human

Collagen sponge

Complete restoration of bone defects

Ito et al. [80]

2011

Osseointegration of dental implants

Canine DPSCs

–

Dog

PRP

High osteogenic potential to assist dental implant integration

Yamada et al. [79]

2011

Mandibular bone defect

Canine DPSCs and stem cells from deciduous teeth

–

Dog

PRP

Well-formed mature bone using both cell lines

Liu et al. [55]

2011

Critical-size alveolar bone defect

Rabbit DPSCs

–

Rabbit

rhBMP2 + nHAC/PL

Early mineralization and excellent bone formation

Ricco et al. [86]

2012

Critical-size cranial bone defect

Human DPSCs

CD34+c-Kit+STRO-1+ (MACS)

Rat

Fibroin scaffolds

Mature bone formation and defect correction

Pisciotta et al. [84]

2012

Critical-size parietal bone defect

Human DPSCs

STRO-1+ (MACS)

Rat

Collagen constructs

Restoration of critical parietal bone defects

Alkaisi et al. [81]

2013

Distracted area of mandibular bone

Human SHEDs

–

Rabbit

–

Enhancement of the bone consolidation period in mandibular distraction osteogenesis

Annibali et al. [77]

2013

Critical-size calvarial bone defect

Human DPSCs/PeSCs

–

Mouse

Porcine collagen + GDPB, β-TCP, Aga/nHA

β-TCP alone is more effective than β-TCP seeded with DPSCs/PeSCs

Giuliani et al. [85]

2013

Mandibular bone defect after tooth extraction

Human DPSCs

CD34+ (MACS)

Human

Collagen sponge

Regeneration of compact-type bone with uniform vascularization

Yasui et al. [50]

2016

Critical-size calvarial bone defect

Human DPSCs

LNGFRLow+THY-1High+ (FACS)

Mouse

Collagen membrane

LNGFRLow+/THY-1High+ DPSCs promote new bone formation to repair critical-size calvarial defects

  1. Aga/nHA a sponge of agarose and nanohydroxyapatite, DPSCs dental pulp stem/progenitor cells, FACS fluorescence-activated cell sorting, GDPB granular deproteinized bovine bone, HA hydroxyapatite, LNGFR low-affinity nerve growth factor, MACS magnetic-activated cell sorting, nHAC/PLA nanohydroxyapatite/collagen/poly(L-lactide), PeSCs periosteal stem cells, PRP platelet-rich plasma, rhBMP-2 recombinant human bone morphogenetic protein 2, SHEDs stem cells from human exfoliated deciduous teeth, TCP tricalcium phosphate, THY-1 thymocyte antigen 1