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Fig. 3 | Inflammation and Regeneration

Fig. 3

From: Applications of reconstituted inflammasomes in a cell-free system to drug discovery and elucidation of the pathogenesis of autoinflammatory diseases

Fig. 3

A possible mechanism of AIM2 inflammasome in a cell-free system. The PYD domain of AIM2 interacts with the HIN-200 domain of AIM2 loosely upon being incubated with no materials. Once a specific ligand poly(dA:dT) stringently interacts with the HIN-200 domain of AIM2 and streptavidin-conjugated donor beads, then the PYD domain of AIM2 apart from the HIN-200 domain of AIM2 opens to interact with the PYD domain of ASC (a). Since the PYD domain of ASC loosely interacts with the CARD domain of ASC, the interaction between the PYD domain of AIM2 and PYD domain of ASC is thought to open the CARD domain of ASC, which will lead to interaction with protein A-conjugated acceptor beads (b)

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Inflammation and Regeneration

ISSN: 1880-8190

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