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Table 1 List of FGFs and their various functions

From: Role of fibroblast growth factors in bone regeneration

Subfamily FGFs Manner of action Prime functions References
FGF1/2 FGF1 Paracrine Patterning of optical vesicle [36]
  FGF2 Paracrine Neuronal, skeletal, vascular tone; heart repair [37,38,39]
FGF4/5/6 FGF4 Paracrine Proliferation of inner cell mass [40]
  FGF5 Paracrine Hair growth cycle regulator [41]
  FGF6 Paracrine Regulation of muscle regeneration [42]
FGF3/7/10/22 FGF3 Paracrine Inner ear formation, regulation of tooth morphogenesis [43, 44]
  FGF7 Paracrine Modulation of hair growth, kidney development [45, 46]
  FGF10 Paracrine Regulator of development of many organs such as brain, limb, lung, pancreas [47, 48]
  FGF22 Paracrine Presynaptic organization in brain development, hair development [49, 50]
FGF9/16/20 FGF9 Paracrine Lung development, maintenance of stemness in nephrons, bone repair, mammalian sex determination [51,52,53]
  FGF16 Paracrine Heart development [54]
  FGF20 Paracrine Inner ear development, maintenance of stemness in nephrons [52, 55]
FGF8/17/18 FGF8 Paracrine Development of brain, limbs, cardiovascular system, craniofacial region [56,57,58,59]
  FGF17 Paracrine Brain development [60]
  FGF18 Paracrine Bone and cartilage development, lung development [22, 61]
FGF11/12/13/14 FGF11 Intracrine Signalling functions during tooth development [62]
  FGF12 Intracrine Unclear  
  FGF13 Intracrine Signaling functions during tooth development [62]
  FGF14 Intracrine Regulation of neurotransmission of motor functions [63]
FGF15/19/21/23 FGF15/19 Endocrine Regulates hepatic glucose metabolism [64]
  FGF21 Endocrine Lipid metabolism regulator [65]
  FGF23 Endocrine Phosphate and vitamin D metabolism [66]
  1. The table shows the subfamilies of various FGFs, FGFs under each subfamily, the manner of action of each FGF, and their prime functions
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Inflammation and Regeneration

ISSN: 1880-8190

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