Table 3 Application of different FGFs in critical-sized bone defect in vivo models
From: Role of fibroblast growth factors in bone regeneration
| Growth factor | Dose | In vivo model | Carrier | Investigations | Effect | References |
|---|---|---|---|---|---|---|
| FGF2 | 5 ng | Mouse calvarial defect (3.5-mm diameter) | Col-HA/PEG hydrogel | Micro CT and histology of bone | Enhanced bone regeneration | [34] |
| BMP2 | 2 μg | |||||
| FGF2 | 10 ng, 100 μg, and 1 μg | Rat mandibular defect (5-mm diameter) | Collagen sponge | Radiological and histological examination | Promotes osteogenesis | [75] |
| FGF2 | 200 μg | Beagle dog periodontal defect (6 × 5 mm: vertical × horizontal) | β-TCP | Bone histomorphometry | Enhances formation of new bone and cementum | [76] |
| FGF18 | 0.5 μg | Mouse calvaria (3-mm diameter) | CHPOA/hydrogel | Micro CT assessment of bone | Synergistically enhanced new bone formation | [28] |
| BMP2 | 0.5 μg | |||||
| FGF2 or FGF9 or FGF18 | 250 ng (P7 mice) or 2.5 μg (P60 mice) | Mouse calvaria defect (2-mm diameter) | Collagen sponge | Micro CT assessment of bone | All FGF ligands promote healing rate in P7 mice. Only FGF18 promotes healing rate in P60 mice | [20] |