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Fig. 3 | Inflammation and Regeneration

Fig. 3

From: The etiopathogenesis of atopic dermatitis: barrier disruption, immunological derangement, and pruritus

Fig. 3

The relationship among itch, barrier disruption and an immunologic aberration. Scratching resulting from itch can worsen a breach in the skin. Dry skin promotes itch by increasing the density of epidermal nerve fibers. Scratching also promotes Th2 chemokines, eosinophil-recruiting chemokines, and thymic stromal lymphopoietin (TSLP). Conversely, immune responses can induce itch via the secretion of a myriad of cytokines that can act as pruritogens

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Inflammation and Regeneration

ISSN: 1880-8190

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