TY - JOUR AU - Matsushita, T. AU - Hasegawa, M. AU - Hamaguchi, Y. AU - Takehara, K. AU - Sato, S. PY - 2006 DA - 2006// TI - Longitudinal analysis of serum cytokine concentrations in systemic sclerosis: association of interleukin 12 elevation with spontaneous regression of skin sclerosis JO - J Rheumatol VL - 33 ID - Matsushita2006 ER - TY - JOUR AU - Murata, M. AU - Fujimoto, M. AU - Matsushita, T. AU - Hamaguchi, Y. AU - Hasegawa, M. AU - Takehara, K. PY - 2008 DA - 2008// TI - Clinical association of serum interleukin-17 levels in systemic sclerosis: is systemic sclerosis a Th17 disease? JO - J Dermatol Sci VL - 50 UR - https://doi.org/10.1016/j.jdermsci.2008.01.001 DO - 10.1016/j.jdermsci.2008.01.001 ID - Murata2008 ER - TY - JOUR AU - Higashi-Kuwata, N. AU - Jinnin, M. AU - Makino, T. AU - Fukushima, S. AU - Inoue, Y. AU - Muchemwa, F. C. PY - 2010 DA - 2010// TI - Characterization of monocyte/macrophage subsets in the skin and peripheral blood derived from patients with systemic sclerosis JO - Arthritis Res Ther VL - 12 UR - https://doi.org/10.1186/ar3066 DO - 10.1186/ar3066 ID - Higashi-Kuwata2010 ER - TY - JOUR AU - Duan, H. AU - Fleming, J. AU - Pritchard, D. K. AU - Amon, L. M. AU - Xue, J. AU - Arnett, H. A. PY - 2008 DA - 2008// TI - Combined analysis of monocyte and lymphocyte messenger RNA expression with serum protein profiles in patients with scleroderma JO - Arthritis Rheum VL - 58 UR - https://doi.org/10.1002/art.23451 DO - 10.1002/art.23451 ID - Duan2008 ER - TY - JOUR AU - Gruschwitz, M. S. AU - Vieth, G. PY - 1997 DA - 1997// TI - Up-regulation of class II major histocompatibility complex and intercellular adhesion molecule 1 expression on scleroderma fibroblasts and endothelial cells by interferon-gamma and tumor necrosis factor alpha in the early disease stage JO - Arthritis Rheum VL - 40 UR - https://doi.org/10.1002/art.1780400321 DO - 10.1002/art.1780400321 ID - Gruschwitz1997 ER - TY - JOUR AU - Jimenez, S. A. PY - 2013 DA - 2013// TI - Role of endothelial to mesenchymal transition in the pathogenesis of the vascular alterations in systemic sclerosis JO - ISRN Rheumatol VL - 2013 UR - https://doi.org/10.1155/2013/835948 DO - 10.1155/2013/835948 ID - Jimenez2013 ER - TY - STD TI - Takahashi T, Asano Y, Sugawara K, Yamashita T, Nakamura K, Saigusa R, et al. Epithelial Fli1 deficiency drives systemic autoimmunity and fibrosis: possible roles in scleroderma. J Exp Med. in press doi: 10.1084/jem.20160247. ID - ref7 ER - TY - JOUR AU - Marangoni, R. G. AU - Korman, B. D. AU - Wei, J. AU - Wood, T. A. AU - Graham, L. V. AU - Whitfield, M. L. PY - 2015 DA - 2015// TI - Myofibroblasts in murine cutaneous fibrosis originate from adiponectin-positive intradermal progenitors JO - Arthritis Rheumatol VL - 67 UR - https://doi.org/10.1002/art.38990 DO - 10.1002/art.38990 ID - Marangoni2015 ER - TY - JOUR AU - Denton, C. P. PY - 2015 DA - 2015// TI - Systemic sclerosis: from pathogenesis to targeted therapy JO - Clin Exp Rheumatol VL - 33 ID - Denton2015 ER - TY - JOUR AU - Asano, Y. AU - Sato, S. PY - 2015 DA - 2015// TI - Vasculopathy in scleroderma JO - Semin Immunopathol VL - 37 UR - https://doi.org/10.1007/s00281-015-0505-5 DO - 10.1007/s00281-015-0505-5 ID - Asano2015 ER - TY - JOUR AU - Khan, K. AU - Xu, S. AU - Nihtyanova, S. AU - Derrett-Smith, E. AU - Abraham, D. AU - Denton, C. P. PY - 2012 DA - 2012// TI - Clinical and pathological significance of interleukin 6 overexpression in systemic sclerosis JO - Ann Rheum Dis VL - 71 UR - https://doi.org/10.1136/annrheumdis-2011-200955 DO - 10.1136/annrheumdis-2011-200955 ID - Khan2012 ER - TY - STD TI - Taniguchi T, Asano Y, Fukasawa T, Yoshizaki A, Sato S. Critical contribution of the interleukin-6/signal transducer and activator of transcription 3 axis to vasculopathy associated with systemic sclerosis. J Dermatol. in press doi: 10.1111/1346-8138.13827. ID - ref12 ER - TY - JOUR AU - Garbers, C. AU - Aparicio-Siegmund, S. AU - Rose-John, S. PY - 2015 DA - 2015// TI - The IL-6/gp130/STAT3 signaling axis: recent advances towards specific inhibition JO - Curr Opin Immunol VL - 34 UR - https://doi.org/10.1016/j.coi.2015.02.008 DO - 10.1016/j.coi.2015.02.008 ID - Garbers2015 ER - TY - JOUR AU - Magrini, E. AU - Cavallaro, U. AU - Bianchi, F. PY - 2015 DA - 2015// TI - Microarray profiling of L1-overexpressing endothelial cells reveals STAT3 activation via IL-6/IL-6Rα axis JO - Genom Data VL - 4 UR - https://doi.org/10.1016/j.gdata.2015.03.017 DO - 10.1016/j.gdata.2015.03.017 ID - Magrini2015 ER - TY - JOUR AU - Dienz, O. AU - Rincon, M. PY - 2009 DA - 2009// TI - The effects of IL-6 on CD4 T cell responses JO - Clin Immunol VL - 130 UR - https://doi.org/10.1016/j.clim.2008.08.018 DO - 10.1016/j.clim.2008.08.018 ID - Dienz2009 ER - TY - JOUR AU - Nakashima, T. AU - Jinnin, M. AU - Yamane, K. AU - Honda, N. AU - Kajihara, I. AU - Makino, T. PY - 2012 DA - 2012// TI - Impaired IL-17 signaling pathway contributes to the increased collagen expression in scleroderma fibroblasts JO - J Immunol VL - 188 UR - https://doi.org/10.4049/jimmunol.1100591 DO - 10.4049/jimmunol.1100591 ID - Nakashima2012 ER - TY - JOUR AU - Shima, Y. AU - Kuwahara, Y. AU - Murota, H. AU - Kitaba, S. AU - Kawai, M. AU - Hirano, T. PY - 2010 DA - 2010// TI - The skin of patients with systemic sclerosis softened during the treatment with anti-IL-6 receptor antibody tocilizumab JO - Rheumatology (Oxford) VL - 49 UR - https://doi.org/10.1093/rheumatology/keq275 DO - 10.1093/rheumatology/keq275 ID - Shima2010 ER - TY - JOUR AU - Fernandes das Neves, M. AU - Oliveira, S. AU - Amaral, M. C. AU - Delgado Alves, J. PY - 2015 DA - 2015// TI - Treatment of systemic sclerosis with tocilizumab JO - Rheumatology (Oxford) VL - 54 UR - https://doi.org/10.1093/rheumatology/keu435 DO - 10.1093/rheumatology/keu435 ID - Fernandes das Neves2015 ER - TY - JOUR AU - Khanna, D. AU - Denton, C. P. AU - Jahreis, A. AU - Laar, J. M. AU - Frech, T. M. AU - Anderson, M. E. PY - 2016 DA - 2016// TI - Safety and efficacy of subcutaneous tocilizumab in adults with systemic sclerosis (faSScinate): a phase 2, randomised, controlled trial JO - Lancet VL - 387 UR - https://doi.org/10.1016/S0140-6736(16)00232-4 DO - 10.1016/S0140-6736(16)00232-4 ID - Khanna2016 ER - TY - JOUR AU - Tsou, P. S. AU - Rabquer, B. J. AU - Ohara, R. A. AU - Stinson, W. A. AU - Campbell, P. L. AU - Amin, M. A. PY - 2016 DA - 2016// TI - Scleroderma dermal microvascular endothelial cells exhibit defective response to pro-angiogenic chemokines JO - Rheumatology (Oxford) VL - 55 UR - https://doi.org/10.1093/rheumatology/kev399 DO - 10.1093/rheumatology/kev399 ID - Tsou2016 ER - TY - JOUR AU - Yamaguchi, Y. AU - Kuwana, M. PY - 2013 DA - 2013// TI - Proangiogenic hematopoietic cells of monocytic origin: roles in vascular regeneration and pathogenic processes of systemic sclerosis JO - Histol Histopathol VL - 28 ID - Yamaguchi2013 ER - TY - JOUR AU - Tourkina, E. AU - Bonner, M. AU - Oates, J. AU - Hofbauer, A. AU - Richard, M. AU - Znoyko, S. PY - 2011 DA - 2011// TI - Altered monocyte and fibrocyte phenotype and function in scleroderma interstitial lung disease: reversal by caveolin-1 scaffolding domain peptide JO - Fibrogenesis Tissue Repair VL - 4 UR - https://doi.org/10.1186/1755-1536-4-15 DO - 10.1186/1755-1536-4-15 ID - Tourkina2011 ER - TY - JOUR AU - Sato, S. AU - Hasegawa, M. AU - Fujimoto, M. AU - Tedder, T. F. AU - Takehara, K. PY - 2000 DA - 2000// TI - Quantitative genetic variation in CD19 expression correlates with autoimmunity JO - J Immunol VL - 165 UR - https://doi.org/10.4049/jimmunol.165.11.6635 DO - 10.4049/jimmunol.165.11.6635 ID - Sato2000 ER - TY - JOUR AU - Saito, E. AU - Fujimoto, M. AU - Hasegawa, M. AU - Komura, K. AU - Hamaguchi, Y. AU - Kaburagi, Y. PY - 2002 DA - 2002// TI - CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse JO - J Clin Invest VL - 109 UR - https://doi.org/10.1172/JCI0215078 DO - 10.1172/JCI0215078 ID - Saito2002 ER - TY - JOUR AU - Hasegawa, M. AU - Hamaguchi, Y. AU - Yanaba, K. AU - Bouaziz, J. D. AU - Uchida, J. AU - Fujimoto, M. PY - 2006 DA - 2006// TI - B-lymphocyte depletion reduces skin fibrosis and autoimmunity in the tight-skin mouse model for systemic sclerosis JO - Am J Pathol VL - 169 UR - https://doi.org/10.2353/ajpath.2006.060205 DO - 10.2353/ajpath.2006.060205 ID - Hasegawa2006 ER - TY - JOUR AU - Yoshizaki, A. PY - 2016 DA - 2016// TI - B lymphocytes in systemic sclerosis: abnormalities and therapeutic targets JO - J Dermatol VL - 43 UR - https://doi.org/10.1111/1346-8138.13184 DO - 10.1111/1346-8138.13184 ID - Yoshizaki2016 ER - TY - JOUR AU - Faurschou, M. AU - Jayne, D. R. PY - 2014 DA - 2014// TI - Anti-B cell antibody therapies for inflammatory rheumatic diseases JO - Annu Rev Med VL - 65 UR - https://doi.org/10.1146/annurev-med-070912-133235 DO - 10.1146/annurev-med-070912-133235 ID - Faurschou2014 ER - TY - JOUR AU - Lafyatis, R. AU - Kissin, E. AU - York, M. AU - Farina, G. AU - Viger, K. AU - Fritzler, M. J. PY - 2009 DA - 2009// TI - B cell depletion with rituximab in patients with diffuse cutaneous systemic sclerosis JO - Arthritis Rheum VL - 60 UR - https://doi.org/10.1002/art.24249 DO - 10.1002/art.24249 ID - Lafyatis2009 ER - TY - JOUR AU - Smith, V. AU - Praet, J. T. AU - Vandooren, B. AU - Cruyssen, B. AU - Naeyaert, J. M. AU - Decuman, S. PY - 2010 DA - 2010// TI - Rituximab in diffuse cutaneous systemic sclerosis: an open-label clinical and histopathological study JO - Ann Rheum Dis VL - 69 UR - https://doi.org/10.1136/ard.2008.095463 DO - 10.1136/ard.2008.095463 ID - Smith2010 ER - TY - JOUR AU - Daoussis, D. AU - Liossis, S. N. AU - Tsamandas, A. C. AU - Kalogeropoulou, C. AU - Kazantzi, A. AU - Sirinian, C. PY - 2010 DA - 2010// TI - Experience with rituximab in scleroderma: results from a 1-year, proof-of-principle study JO - Rheumatology (Oxford) VL - 49 UR - https://doi.org/10.1093/rheumatology/kep093 DO - 10.1093/rheumatology/kep093 ID - Daoussis2010 ER - TY - JOUR AU - Jordan, S. AU - Distler, J. H. AU - Maurer, B. AU - Huscher, D. AU - Laar, J. M. AU - Allanore, Y. PY - 2015 DA - 2015// TI - Effects and safety of rituximab in systemic sclerosis: an analysis from the European Scleroderma Trial and Research (EUSTAR) group JO - Ann Rheum Dis VL - 74 UR - https://doi.org/10.1136/annrheumdis-2013-204522 DO - 10.1136/annrheumdis-2013-204522 ID - Jordan2015 ER - TY - STD TI - Daoussis D, Melissaropoulos K, Sakellaropoulos G, Antonopoulos I, Markatseli TE, Simopoulou T, et al. A multicenter, open-label, comparative study of B-cell depletion therapy with Rituximab for systemic sclerosis-associated interstitial lung disease. Semin Arthritis Rheum. in press doi: 10.1016/j.semarthrit.2016.10.003. ID - ref32 ER - TY - JOUR AU - Bosello, S. L. AU - Luca, G. AU - Rucco, M. AU - Berardi, G. AU - Falcione, M. AU - Danza, F. M. PY - 2015 DA - 2015// TI - Long-term efficacy of B cell depletion therapy on lung and skin involvement in diffuse systemic sclerosis JO - Semin Arthritis Rheum VL - 44 UR - https://doi.org/10.1016/j.semarthrit.2014.09.002 DO - 10.1016/j.semarthrit.2014.09.002 ID - Bosello2015 ER - TY - JOUR AU - Daoussis, D. AU - Antonopoulos, I. AU - Liossis, S. N. AU - Yiannopoulos, G. AU - Andonopoulos, A. P. PY - 2012 DA - 2012// TI - Treatment of systemic sclerosis-associated calcinosis: a case report of rituximab-induced regression of CREST-related calcinosis and review of the literature JO - Semin Arthritis Rheum VL - 41 UR - https://doi.org/10.1016/j.semarthrit.2011.11.007 DO - 10.1016/j.semarthrit.2011.11.007 ID - Daoussis2012 ER - TY - JOUR AU - Khor, C. G. AU - Chen, X. L. AU - Lin, T. S. AU - Lu, C. H. AU - Hsieh, S. C. PY - 2014 DA - 2014// TI - Rituximab for refractory digital infarcts and ulcers in systemic sclerosis JO - Clin Rheumatol VL - 33 UR - https://doi.org/10.1007/s10067-014-2579-1 DO - 10.1007/s10067-014-2579-1 ID - Khor2014 ER - TY - JOUR AU - Maslyanskiy, A. L. AU - Lapin, S. V. AU - Kolesova, E. P. AU - Penin, I. N. AU - Cheshuina, M. D. AU - Feist, E. PY - 2014 DA - 2014// TI - Effects of rituximab therapy on elastic properties of vascular wall in patients with progressive systemic sclerosis JO - Clin Exp Rheumatol VL - 32 ID - Maslyanskiy2014 ER - TY - JOUR AU - Varga, J. AU - Pasche, B. PY - 2009 DA - 2009// TI - Transforming growth factor beta as a therapeutic target in systemic sclerosis JO - Nat Rev Rheumatol VL - 5 UR - https://doi.org/10.1038/nrrheum.2009.26 DO - 10.1038/nrrheum.2009.26 ID - Varga2009 ER - TY - JOUR AU - Gruschwitz, M. AU - Müller, P. U. AU - Sepp, N. AU - Hofer, E. AU - Fontana, A. AU - Wick, G. PY - 1990 DA - 1990// TI - Transcription and expression of transforming growth factor type β in the skin of progressive systemic sclerosis: a mediator of fibrosis? JO - J Invest Dermatol VL - 94 UR - https://doi.org/10.1111/1523-1747.ep12874503 DO - 10.1111/1523-1747.ep12874503 ID - Gruschwitz1990 ER - TY - JOUR AU - Querfeld, C. AU - Eckes, B. AU - Huerkamp, C. AU - Krieg, T. AU - Sollberg, S. PY - 1999 DA - 1999// TI - Expression of TGF-β1, -β2 and -β3 in localized and systemic scleroderma JO - J Dermatol Sci VL - 21 UR - https://doi.org/10.1016/S0923-1811(99)00008-0 DO - 10.1016/S0923-1811(99)00008-0 ID - Querfeld1999 ER - TY - JOUR AU - Kulozik, M. AU - Hogg, A. AU - Lankat-Buttgereit, B. AU - Krieg, T. PY - 1990 DA - 1990// TI - Co-localization of transforming growth factor β2 with α1(I) procollagen mRNA in tissue sections of patients with systemic sclerosis JO - J Clin Invest VL - 86 UR - https://doi.org/10.1172/JCI114793 DO - 10.1172/JCI114793 ID - Kulozik1990 ER - TY - JOUR AU - Asano, Y. AU - Ihn, H. AU - Yamane, K. AU - Kubo, M. AU - Tamaki, K. PY - 2004 DA - 2004// TI - Impaired Smad7-Smurf-mediated negative regulation of TGF-β signaling in scleroderma fibroblasts JO - J Clin Invest VL - 113 UR - https://doi.org/10.1172/JCI16269 DO - 10.1172/JCI16269 ID - Asano2004 ER - TY - JOUR AU - Asano, Y. AU - Ihn, H. AU - Yamane, K. AU - Jinnin, M. AU - Mimura, Y. AU - Tamaki, K. PY - 2005 DA - 2005// TI - Increased expression of integrin αVβ3 contributes to the establishment of autocrine TGF-β signaling in scleroderma fibroblasts JO - J Immunol VL - 175 UR - https://doi.org/10.4049/jimmunol.175.11.7708 DO - 10.4049/jimmunol.175.11.7708 ID - Asano2005 ER - TY - JOUR AU - Asano, Y. AU - Ihn, H. AU - Yamane, K. AU - Kubo, M. AU - Tamaki, K. PY - 2004 DA - 2004// TI - Increased expression levels of integrin αVβ5 on scleroderma fibroblasts JO - Am J Pathol VL - 164 UR - https://doi.org/10.1016/S0002-9440(10)63215-4 DO - 10.1016/S0002-9440(10)63215-4 ID - Asano2004 ER - TY - JOUR AU - Asano, Y. AU - Ihn, H. AU - Yamane, K. AU - Jinnin, M. AU - Mimura, Y. AU - Tamaki, K. PY - 2005 DA - 2005// TI - Involvement of αVβ5 integrin-mediated activation of latent transforming growth factor β1 in autocrine transforming growth factor β signaling in systemic sclerosis fibroblasts JO - Arthritis Rheum VL - 52 UR - https://doi.org/10.1002/art.21246 DO - 10.1002/art.21246 ID - Asano2005 ER - TY - JOUR AU - Asano, Y. AU - Ihn, H. AU - Yamane, K. AU - Jinnin, M. AU - Tamaki, K. PY - 2006 DA - 2006// TI - Increased expression of integrin αVβ5 induces the myofibroblastic differentiation of dermal fibroblasts JO - Am J Pathol VL - 168 UR - https://doi.org/10.2353/ajpath.2006.041306 DO - 10.2353/ajpath.2006.041306 ID - Asano2006 ER - TY - JOUR AU - Mimura, Y. AU - Ihn, H. AU - Jinnin, M. AU - Asano, Y. AU - Yamane, K. AU - Tamaki, K. PY - 2005 DA - 2005// TI - Constitutive thrombospondin-1 overexpression contributes to autocrine transforming growth factor-β signaling in cultured scleroderma fibroblasts JO - Am J Pathol VL - 166 UR - https://doi.org/10.1016/S0002-9440(10)62362-0 DO - 10.1016/S0002-9440(10)62362-0 ID - Mimura2005 ER - TY - JOUR AU - Denton, C. P. AU - Merkel, P. A. AU - Furst, D. E. AU - Khanna, D. AU - Emery, P. AU - Hsu, V. M. PY - 2007 DA - 2007// TI - Recombinant human anti-transforming growth factor β1 antibody therapy in systemic sclerosis: a multicenter, randomized, placebo-controlled phase I/II trial of CAT-192 JO - Arthritis Rheum VL - 56 UR - https://doi.org/10.1002/art.22289 DO - 10.1002/art.22289 ID - Denton2007 ER - TY - JOUR AU - Rice, L. M. AU - Padilla, C. M. AU - McLaughlin, S. R. AU - Mathes, A. AU - Ziemek, J. AU - Goummih, S. PY - 2015 DA - 2015// TI - Fresolimumab treatment decreases biomarkers and improves clinical symptoms in systemic sclerosis patients JO - J Clin Invest VL - 125 UR - https://doi.org/10.1172/JCI77958 DO - 10.1172/JCI77958 ID - Rice2015 ER - TY - JOUR AU - Farina, G. AU - Lafyatis, D. AU - Lemaire, R. AU - Lafyatis, R. PY - 2010 DA - 2010// TI - A four-gene biomarker predicts skin disease in patients with diffuse cutaneous systemic sclerosis JO - Arthritis Rheum VL - 62 UR - https://doi.org/10.1002/art.27220 DO - 10.1002/art.27220 ID - Farina2010 ER - TY - JOUR AU - Castiglione, F. AU - Tieri, P. AU - Palma, A. AU - Jarrah, A. S. PY - 2016 DA - 2016// TI - Statistical ensemble of gene regulatory networks of macrophage differentiation JO - BMC Bioinform VL - 17 UR - https://doi.org/10.1186/s12859-016-1363-4 DO - 10.1186/s12859-016-1363-4 ID - Castiglione2016 ER -