From: Use of mesenchymal stem cells seeded on the scaffold in articular cartilage repair
Design for Implantation | Animal model | Follow-up period (months) | Finding | Ref. |
---|---|---|---|---|
BM-MSC seeded on TCP scaffold | Sheep | 6 | Proteoglycan and type II collagen | [66] |
BM-MSC seeded on PLA scaffold | Dog | 1.5 | Coverage of chondral defect | [67] |
BM-MSC seeded on HA scaffold | Mini-pig | 3 | Coverage of chondral defect | [14] |
BMDC seeded on HA scaffold | Goat | 6 | Coverage of chondral defect, proteoglycan and type II collagen | [55] |
BM-MSC seeded on type I collagen scaffold | Sheep | 6 | Hyaline-like cartilage | [15] |
BMDC seeded on PGA or PLGA scaffold | Sheep | 3 | Hyaline-like cartilage | [16] |
BM-MSC seeded on type I collagen scaffold | Sheep | 12 | Type II collagen | [68] |
BM-MSC seeded on HA scaffold | Horse | 12 | No difference in chondral surface | [56] |
BM-MSC seeded on type II collagen scaffold | Pig | 2 | Hyaline-like cartilage | [69] |
BM-MSC suspended in fibrin glue | Goat | 6 | Improved cartilage tissue | [70] |
BM-MSC seeded on PGA-hyaluronan | Rabbit | 1.5 | Hyaline-like cartilage | [71] |
BM-MSC sheet-encapsulated MSC on PLGA scaffold | Rabbit | 3 | Hyaline-like cartilage | [43] |
MSC seeded on PLGA-based TGF-β3-releasing microspheres | Mice | 1.5 | Hyaline-like cartilage | [72] |