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Table 1 Application of MSC seeded onto various types of scaffolds into animal models of articular cartilage defect

From: Use of mesenchymal stem cells seeded on the scaffold in articular cartilage repair

Design for Implantation

Animal model

Follow-up period (months)

Finding

Ref.

BM-MSC seeded on TCP scaffold

Sheep

6

Proteoglycan and type II collagen

[66]

BM-MSC seeded on PLA scaffold

Dog

1.5

Coverage of chondral defect

[67]

BM-MSC seeded on HA scaffold

Mini-pig

3

Coverage of chondral defect

[14]

BMDC seeded on HA scaffold

Goat

6

Coverage of chondral defect, proteoglycan and type II collagen

[55]

BM-MSC seeded on type I collagen scaffold

Sheep

6

Hyaline-like cartilage

[15]

BMDC seeded on PGA or PLGA scaffold

Sheep

3

Hyaline-like cartilage

[16]

BM-MSC seeded on type I collagen scaffold

Sheep

12

Type II collagen

[68]

BM-MSC seeded on HA scaffold

Horse

12

No difference in chondral surface

[56]

BM-MSC seeded on type II collagen scaffold

Pig

2

Hyaline-like cartilage

[69]

BM-MSC suspended in fibrin glue

Goat

6

Improved cartilage tissue

[70]

BM-MSC seeded on PGA-hyaluronan

Rabbit

1.5

Hyaline-like cartilage

[71]

BM-MSC sheet-encapsulated MSC on PLGA scaffold

Rabbit

3

Hyaline-like cartilage

[43]

MSC seeded on PLGA-based TGF-β3-releasing microspheres

Mice

1.5

Hyaline-like cartilage

[72]

  1. BM-MSC bone marrow-derived mesenchymal stem cells, TCP tricalcium phosphate, PLA polylactic acid, HA hyaluronic acid, PGA polyglycolic acid, PLGA poly-lactic and co-glycolic acids, TGF-β3 transforming growth factor-β3