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Table 1 Application of MSC seeded onto various types of scaffolds into animal models of articular cartilage defect

From: Use of mesenchymal stem cells seeded on the scaffold in articular cartilage repair

Design for Implantation Animal model Follow-up period (months) Finding Ref.
BM-MSC seeded on TCP scaffold Sheep 6 Proteoglycan and type II collagen [66]
BM-MSC seeded on PLA scaffold Dog 1.5 Coverage of chondral defect [67]
BM-MSC seeded on HA scaffold Mini-pig 3 Coverage of chondral defect [14]
BMDC seeded on HA scaffold Goat 6 Coverage of chondral defect, proteoglycan and type II collagen [55]
BM-MSC seeded on type I collagen scaffold Sheep 6 Hyaline-like cartilage [15]
BMDC seeded on PGA or PLGA scaffold Sheep 3 Hyaline-like cartilage [16]
BM-MSC seeded on type I collagen scaffold Sheep 12 Type II collagen [68]
BM-MSC seeded on HA scaffold Horse 12 No difference in chondral surface [56]
BM-MSC seeded on type II collagen scaffold Pig 2 Hyaline-like cartilage [69]
BM-MSC suspended in fibrin glue Goat 6 Improved cartilage tissue [70]
BM-MSC seeded on PGA-hyaluronan Rabbit 1.5 Hyaline-like cartilage [71]
BM-MSC sheet-encapsulated MSC on PLGA scaffold Rabbit 3 Hyaline-like cartilage [43]
MSC seeded on PLGA-based TGF-β3-releasing microspheres Mice 1.5 Hyaline-like cartilage [72]
  1. BM-MSC bone marrow-derived mesenchymal stem cells, TCP tricalcium phosphate, PLA polylactic acid, HA hyaluronic acid, PGA polyglycolic acid, PLGA poly-lactic and co-glycolic acids, TGF-β3 transforming growth factor-β3