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Table 2 Application of MSC seeded onto different types of scaffolds into patients with damaged articular cartilage

From: Use of mesenchymal stem cells seeded on the scaffold in articular cartilage repair

Technique n; Sex; Age (years) (mean ± SD) Follow-up period (months) Finding Ref.
BM-MSC in type I collagen gel 1; M (31) 12 Hyaline-like cartilage [49]
BM-MSC within type I collagen gel on a collagen scaffold seeded on PLA scaffold 3; 2 M, 1F (32–45) 18 Coverage of chondral defect [73]
BMDC suspended in collagen or seeded on HA scaffold 48; 27 M, 21F (28 ± 9) 24–35 Coverage of chondral defect and hypertrophic cartilage [57]
BMDC seeded on HA scaffold supplemented with platelet-rich fibrin 20; 12 M, 8F (28 ± 9) 29 ± 4 Proteoglycan and type II collagen [58]
BMDC seeded on HA scaffold supplemented with platelet-rich fibrin 81; 47 M, 34F (30 ± 8) 59 ± 26 Hyaline-like cartilage [74]
BM-MSC within platelet-rich fibrin glue 5; 4 M, 1F (25) 12 Coverage of chondral defect [75]
BM-MSC covered by periosteum 72; 38 M, 34F (44 ± 11) 24 Aggrecan and type II collagen [76]
BMDC with batroxobin covered by type I/III collagen matrix 15; 10 M, 5F (48) 24–38 Coverage of chondral defect [77]
BM-MSC seeded on type I collagen scaffold supplemented with fibrin glue 2; 2 M (24–25) 30–31 Partial coverage of chondral defect [78]
Peripheral blood-derived MSC with HA 5; 1 M, 4F (39 ± 11) 10–26 Partial coverage of chondral defect [79]
BMDC within fibrin glue and coverage with collagen and collagen membrane 1; M; 37 yrs 24 Partial coverage of chondral defect [80]
BMDC in fibrin glue and coverage with a PGA + HA membrane 9; 5 M, 4F (48 ± 9) 20–24 Hyaline-like cartilage [81]
BMDC in collagen/platelet paste or seeded on HA or seeded on HA scaffold supplemented with platelet gel 49; 27 M, 22F (28 ± 9) 48 Coverage of chondral defect in 45% [59]
Peripheral blood-derived MSC and HA 49; 17 M, 32F (37 ± 7) 24 Partial coverage of chondral defect [18]
  1. BM-MSC bone marrow-derived mesenchymal stem cells, PLA polylactic acid, HA hyaluronic acid, PGA polyglycolic acid