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Table 1 Functional similarities of microRNAs in different types of TSCs

From: Functional similarities of microRNAs across different types of tissue stem cells in aging

microRNA family Differentiation (specification) Proliferation, survival, and apoptosis Secretion and inflammation Tumorigenesis Others
miR-17/106 MSCs (↑Ad, ↑Os) [22, 27] NSCs (↑N, ↓G) [25] HSCs (↑B, ↑Ly, ↑My) [28,29,30] ↑HSCs [28,29,30] MSCs (↑Gdf6 and etc.) [22] Lymphoma [28,29,30]  
miR-125b HSCs (↑Ly, ↑My) [35, 36]MSCs (↑Ad, ↑Os) [42] Skin stem cells (↓Epi, ↓Oil, ↓HF) [43] ↑HSCs [35, 36]↑NSCs [41] ↑Skin stem cells [43] HSCs (↓CCL4, ↑NF-κB, ↓TNFAIP3) [37, 39, 40] Breast cancer [44] Hepatocellular carcinoma [45] Leukemia [46] Skin tumor [47] Stomach adenocarcinoma [48] ↑HSC engraftment [35, 36]
miR-181 HSCs (↑Ly) [51] Myoblasts (↑Muscle) [52] ↑Beta cells [58] HSCs (↓IL-1α, ↓c-fos, ↓NF-κB) [40] MSCs (↑IL-6) [53] Hepatic cancer stem cells [54] Breast cancer [55] Leukemia [56] ↑T cell receptor sensitivity [57] ↑Blood-brain barrier destruction [59]
  1. ↑: promotion/positive regulation, ↓: inhibition/negative regulation, Ad: adipocytes, Os: Osteoblasts, N: neurons, G: glial cells, B: B cells, Ly: lymphocytes, My: myeloid cells, Epi: epidermal cells, Oil: oil-gland cells, HF: hair follicle cells