Functional similarities of microRNAs across different types of tissue stem cells in aging

Table 1 Functional similarities of microRNAs in different types of TSCs

microRNA family	Differentiation (specification)	Proliferation, survival, and apoptosis	Secretion and inflammation	Tumorigenesis	Others
miR-17/106	MSCs (↑Ad, ↑Os) [22, 27] NSCs (↑N, ↓G) [25] HSCs (↑B, ↑Ly, ↑My) [28,29,30]	↑HSCs [28,29,30]	MSCs (↑Gdf6 and etc.) [22]	Lymphoma [28,29,30]
miR-125b	HSCs (↑Ly, ↑My) [35, 36]MSCs (↑Ad, ↑Os) [42] Skin stem cells (↓Epi, ↓Oil, ↓HF) [43]	↑HSCs [35, 36]↑NSCs [41] ↑Skin stem cells [43]	HSCs (↓CCL4, ↑NF-κB, ↓TNFAIP3) [37, 39, 40]	Breast cancer [44] Hepatocellular carcinoma [45] Leukemia [46] Skin tumor [47] Stomach adenocarcinoma [48]	↑HSC engraftment [35, 36]
miR-181	HSCs (↑Ly) [51] Myoblasts (↑Muscle) [52]	↑Beta cells [58]	HSCs (↓IL-1α, ↓c-fos, ↓NF-κB) [40] MSCs (↑IL-6) [53]	Hepatic cancer stem cells [54] Breast cancer [55] Leukemia [56]	↑T cell receptor sensitivity [57] ↑Blood-brain barrier destruction [59]

↑: promotion/positive regulation, ↓: inhibition/negative regulation, Ad: adipocytes, Os: Osteoblasts, N: neurons, G: glial cells, B: B cells, Ly: lymphocytes, My: myeloid cells, Epi: epidermal cells, Oil: oil-gland cells, HF: hair follicle cells

ISSN: 1880-8190