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Table 1 Functional similarities of microRNAs in different types of TSCs

From: Functional similarities of microRNAs across different types of tissue stem cells in aging

microRNA family Differentiation (specification) Proliferation, survival, and apoptosis Secretion and inflammation Tumorigenesis Others
miR-17/106 MSCs (↑Ad, ↑Os) [22, 27]
NSCs (↑N, ↓G) [25]
HSCs (↑B, ↑Ly, ↑My) [28,29,30]
↑HSCs [28,29,30] MSCs (↑Gdf6 and etc.) [22] Lymphoma [28,29,30]  
miR-125b HSCs (↑Ly, ↑My) [35, 36]MSCs (↑Ad, ↑Os) [42]
Skin stem cells (↓Epi, ↓Oil, ↓HF) [43]
↑HSCs [35, 36]↑NSCs [41]
↑Skin stem cells [43]
HSCs (↓CCL4, ↑NF-κB, ↓TNFAIP3) [37, 39, 40] Breast cancer [44]
Hepatocellular carcinoma [45]
Leukemia [46]
Skin tumor [47]
Stomach adenocarcinoma [48]
↑HSC engraftment [35, 36]
miR-181 HSCs (↑Ly) [51]
Myoblasts (↑Muscle) [52]
↑Beta cells [58] HSCs (↓IL-1α, ↓c-fos, ↓NF-κB) [40]
MSCs (↑IL-6) [53]
Hepatic cancer stem cells [54]
Breast cancer [55]
Leukemia [56]
↑T cell receptor sensitivity [57]
↑Blood-brain barrier destruction [59]
  1. ↑: promotion/positive regulation, ↓: inhibition/negative regulation, Ad: adipocytes, Os: Osteoblasts, N: neurons, G: glial cells, B: B cells, Ly: lymphocytes, My: myeloid cells, Epi: epidermal cells, Oil: oil-gland cells, HF: hair follicle cells