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Fig. 2 | Inflammation and Regeneration

Fig. 2

From: Maintenance of memory-type pathogenic Th2 cells in the pathophysiology of chronic airway inflammation

Fig. 2

iBALT is induced under conditions of chronic allergic inflammation in both mice and humans. a The intra-nasal administration of the antigen resulted in iBALT formation in the lungs of mice. b iBALT included memory Th2 cells, MHC-class ll+ cells, B220+ cells, CD11c+ cells, VCAM1+ cells, and CD21+ cells. c The memory Th2 cells showed greater accumulation in the lymphoid areas than in the non-lymphoid areas. d Memory Th2 cells in the lung produced more Th2 cytokines compared to those from memory Th2 cells in the spleen. e IL-7-producing cells and Ly5.1+ memory Th2 cells were detected in mice iBALT. f Ectopic lymphoid structures were generated in the polyps of patients with ECRS. g Podoplanin-positive lymphatics were increased in the polyps of patients with ECRS. (Shinoda et al. PNAS(2016) Copyright (2016) National Academy of Sciences). KJ: OVA-specific T cell receptor

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