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Fig. 3 | Inflammation and Regeneration

Fig. 3

From: CTGF in kidney fibrosis and glomerulonephritis

Fig. 3

CTGF mediates chemotaxis and adhesion of macrophages as well as ECM production in mesangial cells. Anti-GBM nephritis elicits upregulation of CTGF in mesangial cells. CTGF derived from mesangial cells increases MCP-1 (CCL2) expression, which induces macrophage migration and ECM proteins, including integrin αv and fibronectin, which contribute macrophage adhesion with mesangial cells

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