Fig. 1

The plasticity of MDSCs in non-neoplastic inflammatory conditions. MDSCs from the bone marrow of CIA mice can differentiate into osteoclasts capable of bone resorption in vitro and in vivo. In the lungs of SKG mice, M-MDSCs differentiate into CD11b⁺Gr1^dim tolerogenic DCs (CD11b⁺Gr1^dim tolDCs), which suppress the progression of ILD