Myeloid-derived suppressor cells in non-neoplastic inflamed organs

Table 1 Comparisons of morphology, phenotype, and function between myeloid-derived cells

	Morphology	Surface phenotype	Immune suppression
Mouse
Neutrophils	Round shape with a segmented nucleus	CD11b⁺Ly6G^hiLy6C^lo	−
Monocytes	Round shape with a indented nucleus	CD11b⁺Ly6G⁻Ly6C^hi	−
Macrophages	Round shape with pseudopodia	CD11b⁺F4/80^hiLy6G⁻Ly6C^lo	−
Dendritic cells	Dendritic shape with polypodia	CD11b⁺CD11c⁺Ly6G⁻Ly6C^−/lo (classical)	−
		CD11b⁻CD11c⁺Ly6G⁻Ly6C⁻ (classical)	−
		CD11b⁻CD11c^loLy6G⁻Ly6C⁺PDCA-1⁺ (plasmacytoid)	−
Fibrocytes	Spindle shape	CD11b⁺ColI⁺Ly6G⁻Ly6C⁺	−
G-MDSCs	Round shape with a banded nucleus	CD11b⁺Ly6G⁺Ly6C^lo	+
M-MDSCs	Round shape with a indented nucleus	CD11b⁺Ly6G⁻Ly6C^hi	++
Human
Neutrophils	Round shape with a segmented nucleus	CD11b⁺CD14⁻CD15⁺CD66b⁺LOX-1⁻	−
Monocytes	Round shape with a indented nucleus	CD14⁺CD15⁻CD16⁻HLA-DR⁺ (classical)	−
		CD14⁺CD15⁻CD16⁺HLA-DR⁺ (intermediate)	−
		CD14⁻CD15⁻CD16⁺HLA-DR⁺ (non-classical)	−
Macrophages	Round shape with pseudopodia	CD14⁺CD15⁻CD16⁺CD80⁺HLA-DR⁺ (M1)	−
Macrophages	Round shape with pseudopodia	CD11b⁺CD14⁺CD15⁻CD206⁺CD163⁺HLA-DR⁺ (M2)	±
Dendritic cells	Dendritic shape with polypodia	CD14⁻CD16⁻CD1C⁺ (classical)	−
		CD14⁻CD16⁻CD141⁺ (classical)	−
		CD14⁻CD16⁻CD303⁺ (plasmacytoid)	–
Fibrocytes	Spindle shape	CD11b⁺ColI⁺CD13⁺CD34⁺CD45RO⁺HLA-DR⁺	−
G-MDSCs	Round shape with a annular nucleus	CD11b⁺CD14⁻CD15⁺CD66b⁺LOX-1⁺	+
M-MDSCs	Round shape with a indented nucleus	CD14⁺CD15⁻HLA-DR^−/lo	++

Abbreviations: HLA human leukocyte antigen, Lox-1 lectin-type oxidized LDL receptor 1, PDCA-1 plasmacytoid dendritic cell antigen-1

ISSN: 1880-8190