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Table 1 PINK1-PARK2-mediated mitophagy in COPD and IPF

From: PINK1-PARK2-mediated mitophagy in COPD and IPF pathogeneses

  References
COPD
 The expression of PINK1 and PARK2
  PINK1 levels in homogenated lung increased [58]
  PARK2 levels in homogenated lung decreased [19]
 The role of mitophagy (the choice by the degree of damage.)
  Increased PINK1-mediated mitophagy enhancing program cell death [58]
  Insufficient PARK2-mediated accelerating cellular senescence [19]
IPF
 The expression of PINK1 and PARK2
  PINK1 levels in AEC II decreased [23]
  PINK1 levels in FF decreased [71]
  PARK2 levels in FF decreased [40]
  PARK2 levels in fibroblast decreased [40]
 The role of mitophagy
  Insufficient PINK1-mediated mitophagy enhancing apoptosis and cellular senescence [23, 70]
  Insufficient PARK2-mediated mitophagy accelerating myofibroblast differentiation  
  1. AEC II: type II alveolar epithelial cells
  2. FF: fibroblast foci