Table 1 PINK1-PARK2-mediated mitophagy in COPD and IPF
From: PINK1-PARK2-mediated mitophagy in COPD and IPF pathogeneses
| Â | References | |
|---|---|---|
COPD | ||
 The expression of PINK1 and PARK2 | ||
  PINK1 levels in homogenated lung | increased | [58] |
  PARK2 levels in homogenated lung | decreased | [19] |
 The role of mitophagy (the choice by the degree of damage.) | ||
  Increased PINK1-mediated mitophagy enhancing program cell death | [58] | |
  Insufficient PARK2-mediated accelerating cellular senescence | [19] | |
IPF | ||
 The expression of PINK1 and PARK2 | ||
  PINK1 levels in AEC II | decreased | [23] |
  PINK1 levels in FF | decreased | [71] |
  PARK2 levels in FF | decreased | [40] |
  PARK2 levels in fibroblast | decreased | [40] |
 The role of mitophagy | ||
  Insufficient PINK1-mediated mitophagy enhancing apoptosis and cellular senescence | ||
  Insufficient PARK2-mediated mitophagy accelerating myofibroblast differentiation |  | |