Fig. 2
From: Molecular mechanisms regulating lifespan and environmental stress responses
A possible model of epigenetic regulation in response to environmental factors. The white area represents environmental circumstances, and the green area represents the plausible responses of organisms to environmental stimuli. Epigenetic alterations (such as histone modification and chromatin remodeling) are known as the hallmarks of aging, and these changes are profoundly dictated by environmental stimuli [3, 4, 49]. Me, histone methylation; Ac, histone acetylation; P, histone phosphorylation